Directory of Antibodies Resources

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Sites about the defense mechanism of the body which are dependent on the humoral aspects of immunity as compared to the cell-mediated aspects which secrete Cytokines. Sites may include the mechanisms of interaction of antibody with antigen, as well as the cascade sequence that this invokes, through the complement system.

Sites may describe the molecular structure of antibodies, their classification and problems associated with their synthesis, such as the glycosylation of recombinant proteins, to mimic mammalian species, but are produced in plant cell host, "Plantibodies".

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Resources in This Category

• Antibodies - Structure and Sequence

  http://www.bioinf.org.uk/abs/
  Attempts to summarize useful information on antibody structure and sequence. Provides a query interface to the Kabat antibody sequence data, general information on antibodies and crystal structures, and links.

• Antibodies and Therapy

  http://users.path.ox.ac.uk/~scobbold/tig/new1/mabth.html
  Article on the history of vaccination, the role of the humoral response in organ and bone marrow transplantation, leukaemia and lymphoma, and rheumatoid disease. Includes links to laboratories at the Therapeutic Antibody Centre, Oxford, UK.

• Antibody Directory

  http://www.antibodydirectory.com/
  A comprehensive directory of various antibodies, antigens, enzymes and proteins for molecular life sciences and biotechnology use.

• Antibody Questions

  http://www.piercenet.com/products/browse.cfm?fldID=0101
  Interface to introduce the various immunoassays in current use, production and purification methods, labeling and assay development, from a manufacturer, with worldwide distribution in Pierce Biotechnology, Inc., Rockford, IL.

• Conjugation of Monoclonal Antibodies

  http://www.drmr.com/abcon/
  Straightforward procedures for conjugation of proteins (mainly antibodies) to fluorescent dyes.

• ExactAntigen

  http://www.exactantigen.com/
  Database for searching and browsing commercial, academic and therapeutical monoclonal antibodies through gene name, accession number, taxonomy, ontology, disease, and amino acid sequences.

• HLA Matching, Antibodies, and You

  http://www.med.umich.edu/trans/transweb/journey/recip_journey/kidney/kidney_blue/kb_15.htm
  Tissue matching and antibody production, for patients undergoing a transplant.

• Humanization bY Design

  http://www.cryst.bbk.ac.uk/~ubcg07s/
  Resources describing the process of creating humanized antibodies, their uses and their history. Maintained by Birkbeck College, London, UK.

• Monoclonal Antibodies

  http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/M/Monoclonals.html
  Introduction, uses (including in human medicine), problems and what may happen in the future.

• Pluckthun, Andreas

  http://www.bioc.uzh.ch/index.php?id=33&L=1
  Laboratory concentrating on protein engineering and directed molecular evolution, especially of immunoglobulins. Includes PDFs of molecular structures, publications since 1985, and contacts at the University of Zurich in Switzerland.

 

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